Preferentiallyexpressedantigeninmelanoma(PRAME)isacancer-testisantigenthatisexpressedinmanycancersandleukemias.Inhealthytissue,PRAMEexpressionislimitedtothetestesandovaries,makingitahighlyattractivecancertarget.PRAMEisanintracellularproteinthatcannotcurrentlybedrugged.Afterproteasomalprocessing,thePRAME–peptideALYVDSLFFL(ALY)ispresentedinthecontextofhumanleukocyteantigenHLA-A*0:01moleculesforrecognitionbytheTcellreceptor(TCR)ofcytotoxicTcells(fromtheoriginalpaper).
Firstly,researchersofthisstudyidentifiedPr0IgG1clonethroughaphage-displaylibraryscreenastheleadclonewhichwasreactivewithALY/HLA-A北京治疗白癜风技术哪家好北京最好白癜风医院在线咨询
转载请注明地址:http://www.cdlawyers.net/zlzq/11819.html
